Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 28, Issue 11, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201706046
Keywords
biomaterials; bioorthogonal chemistry; dynamic materials; engineered extracellular matrix; hydrogels
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Funding
- National Science Foundation [DMR 1508006]
- California Institute for Regenerative Medicine [RT3-07948]
- National Institutes of Health [R21 EB020235, R21 HL138042, U19 AI116484]
- NIH NRSA predoctoral fellowship [F31 EB020502]
- Siebel Scholars fellowship
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R21HL138042] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI116484] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB020235] Funding Source: NIH RePORTER
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Hydrogels are commonly used as engineered extracellular matrix (ECM) mimics in applications ranging from tissue engineering to in vitro disease models. Ideal mechanisms used to crosslink ECM-mimicking hydrogels do not interfere with the biology of the system. However, most common hydrogel crosslinking chemistries exhibit some form of crossreactivity. The field of bioorthogonal chemistry has arisen to address the need for highly specific and robust reactions in biological contexts. Accordingly, bioorthogonal crosslinking strategies are incorporated into hydrogel design, allowing for gentle and efficient encapsulation of cells in various hydrogel materials. Furthermore, the selective nature of bioorthogonal chemistries can permit dynamic modification of hydrogel materials in the presence of live cells and other biomolecules to alter matrix mechanical properties and biochemistry on demand. This review provides an overview of bioorthogonal strategies used to prepare cell-encapsulating hydrogels and highlights the potential applications of bioorthogonal chemistries in the design of dynamic engineered ECMs.
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