Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 28, Issue 14, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201707077
Keywords
bone marrow mesenchymal stem cells; gold; peripheral nerve regeneration; polycaprolactone; polydopamine; Schwann cells
Categories
Funding
- Projects of National Science Foundation of China [81570992, 81571261]
- Projects of National Science Foundation of Shanghai, China [17401901000]
- SUMHS Seed Foundation Project [HMSF-16-21-010]
- Science and Technology Development Foundation of Pudong New District, Shanghai, China [PKJ2016-Y55, PWZxq2017-03]
- National Science and Technology Major Projects for Major New Drugs Innovation and Development [2017ZX09101005-008-002]
- Interdisciplinary Program of Shanghai Jiao Tong University [YG2015MS06, YG2017MS22, YG2015QN12, YG2017QN56, YG2016QN22]
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Conductive nerve guidance channels are promising alternative therapies in peripheral nerve tissue engineering because they have excellent biocompatibility, biodegradation, and electrical conductivity. Gold, a kind of conductive material, is investigated widely concerning its potential roles in promoting peripheral nerve repair. In the present study, a polydopamine-coated gold/polycaprolactone nanoscaffold is fabricated via a multilayer molding method and its proliferative, adhesive, and neural differentiation potential for bone marrow mesenchymal stem cells (BMSCs) and Schwann cells (SCs) in vitro is evaluated. Functional, electrophysiological evaluation, and morphological assessment all exhibit satisfactory recovery of sciatic nerves with increased thickness and number of myelinated fibers in vivo. In addition, increased microvessels are confirmed in gold nanocomposite channels, indicating their potential benefits in angiogenesis. Functional regeneration is further enhanced by neurotrophic growth factors released from BMSC and SC loading. The gold nanocomposite channel will have great potential in peripheral nerve restoration.
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