Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 126, Issue -, Pages 96-112Publisher
ELSEVIER
DOI: 10.1016/j.addr.2017.09.008
Keywords
Ocular drug delivery; Physiological barriers; Electrical fields; lontophoresis; Electroporation; Sonophoresis; Microneedles
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Funding
- Health Research Council of New Zealand [14/018]
- Buchanan Charitable Foundation
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Overcoming the physiological barriers in the eye remains a key obstacle in the field of ocular drug delivery.While ocular barriers naturally have a protective function, they also limit drug entry into the eye. Various pharmaceutical strategies, such as novel formulations and physical force-based techniques, have been investigated to weaken these barriers and transport therapeutic agents effectively to both the anterior and the posterior segments of the eye. This review summarizes and discusses the recent research progress in the field of ocular drug delivery with a focus on the application of physical methods, including electrical fields, sonophoresis, and microneedles, which can enhance penetration efficiency by transiently disrupting the ocular barriers in a minimally or non-in-vasive manner. (C) 2017 Elsevier B.V. All rights reserved.
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