Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 127, Issue -, Pages 138-166Publisher
ELSEVIER
DOI: 10.1016/j.addr.2018.04.008
Keywords
Wound healing; Drug delivery; Transdermal delivery; Microtechnologies; Nanotechnologies
Categories
Funding
- National Institutes of Health [HL092836, DE019024, EB012597, AR057837, DE021468, HL099073, EB008392]
- University of Nebraska, Lincoln
- Belgian American Educational Foundation (BAEF)
- King Baudouin Foundation (KBS)
- National Centre for Research and Development [STRATEGMED1/233224/10/NCBR/2014]
- Nebraska Tobacco Settlement Biomedical Research Enhancement Funds
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Chronic, non-healing wounds place a significant burden on patients and healthcare systems, resulting in impaired mobility, limb amputation, or even death. Chronic wounds result from a disruption in the highly orchestrated cascade of events involved in wound closure. Significant advances in our understanding of the pathophysiology of chronic wounds have resulted in the development of drugs designed to target different aspects of the impaired processes. However, the hostility of the wound environment rich in degradative enzymes and its elevated pH, combined with differences in the time scales of different physiological processes involved in tissue regeneration require the use of effective drug delivery systems. In this review, we will first discuss the pathophysiology of chronic wounds and then the materials used for engineering drug delivery systems. Different passive and active drug delivery systems used in wound care will be reviewed. In addition, the architecture of the delivery platform and its ability to modulate drug delivery are discussed. Emerging technologies and the opportunities for engineering more effective wound care devices are also highlighted. (C) 2018 Elsevier B.V. All rights reserved.
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