Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 129, Issue -, Pages 376-393Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2017.12.018
Keywords
Blood derivatives; Biomaterials; Wound healing; Regenerative medicine; Delivery; Tissue engineering; Platelet
Categories
Funding
- FCT/MCTES (Fundacao para a Ciencia e a Tecnologia/Ministerio da Ciencia, Tecnologia, e Ensino Superior)
- Fundo Social Europeu atraves do Programa Operational do Capital Humano (FSE/POCH) [PD/59/2013 for PD/BD/113807/2015]
- European Union [706996]
- RECOGNIZE [UTAP-ICDT/CTM-BIO/0023/2014]
- NORTE2020 [UTAP-ICDT/CTM-BIO/0023/2014]
- [SFRH/BPD/112459/2015]
- Marie Curie Actions (MSCA) [706996] Funding Source: Marie Curie Actions (MSCA)
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Blood components play key roles in the modulation of the wound healing process and, together with the provisional fibrin matrix ability to selectively bind bioactive molecules and control its spatial-temporal presentation, define the complex microenvironment that characterize this biological process. As a biomimetic approach, the use of blood derivatives in regenerative strategies has awakened as a source of multiple therapeutic biomolecules. Nevertheless, and despite their clinical relevance, blood derivatives have been showing inconsistent therapeutic results due to several factors, including proper control over their delivery mechanisms. Herein, we highlight recent trends on the use biomaterials to protect, sequester and deliver these pools of biomolecules in tissue engineering and regenerative medicine approaches. Particular emphasis is given to strategies that enable to control their spatiotemporal delivery and improve the selectivity of presentation profiles of the biomolecules derived from blood derivatives rich in platelets. Finally, we discussed possible directions for biomaterials design to potentiate the aimed regenerative effects of blood derivatives and achieve efficient therapies. (C) 2017 Elsevier B.V. All rights reserved.
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