Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 127, Issue -, Pages 167-184Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2018.03.007
Keywords
Hydrogel; Injectable; Skin wounds; Regeneration
Categories
Funding
- National Institute of General Medical Science [T32 GM067555-11]
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Hydrogels have been utilized in regenerative applications for many decades because of their biocompatibility and similarity in structure to the native extracellular matrix. Initially, these materials were formed outside of the patient and implanted using invasive surgical techniques. However, advances in synthetic chemistry and materials science have now provided researchers with a library of techniques whereby hydrogel formation can occur in situ upon delivery through standard needles. This provides an avenue to minimally invasively deliver therapeutic payloads, fill complex tissue defects, and induce the regeneration of damaged portions of the body. In this review, we highlight these injectable therapeutic hydrogel biomaterials in the context of drug delivery and tissue regeneration for skin wound repair. (C) 2018 Elsevier B.V. All rights reserved.
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