Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 128, Issue -, Pages 29-53Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2018.04.001
Keywords
Microfluidics; Drug delivery; Nanotechnology; Nanomedicine; Organ-on-a-chip; 3D culture
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [NRF-2015R1A2A1A09005662, 2016R1A4A1010796]
- American Heart Association National Scientist Development Grant [15SDG25080314]
- National Science Foundation CAREER award [CMMI 1653006]
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Microfluidic technologies employ nano and microscale fabrication techniques to develop highly controllable and reproducible fluidic microenvironments. Utilizing microfluidics, lead compounds can be produced with the controlled physicochemical properties, characterized in a high-throughput fashion, and evaluated in in vitro biomimetic models of human organs; organ-on-a-chip. As a step forward from conventional in vitro culture methods, microfluidics shows promise in effective preclinical testing of nanoparticle-based drug delivery. This review presents a curated selection of state-of-the-art microfluidic platforms focusing on the fabrication, characterization, and assessment of nanoparticles for drug delivery applications. We also discuss the current challenges and future prospects of nanoparticle drug delivery development using microfluidics. (C) 2018 Published by Elsevier B.V.
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