Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 124, Issue -, Pages 107-124Publisher
ELSEVIER
DOI: 10.1016/j.addr.2017.11.002
Keywords
Nanoparticle formulation strategies; Corona formation; Digestive tract; Respiratory tract; Luminal content; Methodologies; Analysis
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Funding
- Danish Council for Independent Research, Technology and Production Sciences [4005-00455, 4093-00062]
- European Commission under Horizon Marie Sklodowska-Curie Actions COFUND scheme [712754]
- Severo Ochoa programme of the Spanish Ministry of Science and Competitiveness [SEV-2014-0425]
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Mucosal administration of drugs and drug delivery systems has gained increasing interest. However, nanoparticles intended to protect and deliver drugs to epithelial surfaces require transport through the surface-lining mucus. Translation from bench to bedside is particularly challenging for mucosal administration since a variety of parameters will influence the specific barrier properties of the mucus including the luminal fluids, the microbiota, the mucus composition and clearance rate, and the condition of the underlying epithelia. Besides, after administration, nanoparticles interact with the mucosal components, forming a biomolecular corona that modulates their behavior and fate after mucosal administration. These interactions are greatly influenced by the nanoparticle properties, and therefore different designs and surface-engineering strategies have been proposed. Overall, it is essential to evaluate these biomolecule-nanoparticle interactions by complementary techniques using complex and relevant mucus barrier matrices. (C) 2017 Elsevier B.V. All rights reserved.
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