Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 129, Issue -, Pages 95-117Publisher
ELSEVIER
DOI: 10.1016/j.addr.2018.03.012
Keywords
Instructive biomaterials; Skin regeneration; Wound healing; Signalling release; in situ tissue engineering
Categories
Funding
- Spanish Ministry of Economy and Competitiveness [MAT2012-38793, MAT2015-68906-R]
- Caixalmpulse Programme by Obra Social La Caixa, project [C115-00015]
- Joint Programme in Healthy Aging Research - Obra Social La Caixa and IBEC
- EIT-Health, Proof of Concept Programme [EIT PoC-2016-SPAIN-03]
- CERCA Programme/Generalitat de Catalunya [ECO/2405/2015]
- Serra Hunter programme [UB-LE-201]
- Training University Lecturers (FPU) subprogramme from MINECO [FPU2012-05310]
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Skin wound healing aims to repair and restore tissue through a multistage process that involves different cells and signalling molecules that regulate the cellular response and the dynamic remodelling of the extracellular matrix. Nowadays, several therapies that combine biomolecule signals (growth factors and cytokines) and cells are being proposed. However, a lack of reliable evidence of their efficacy, together with associated issues such as high costs, a lack of standardization, no scalable processes, and storage and regulatory issues, are hampering their application. In situ tissue regeneration appears to be a feasible strategy that uses the body's own capacity for regeneration by mobilizing host endogenous stem cells or tissue specific progenitor cells to the wound site to promote repair and regeneration. The aim is to engineer instructive systems to regulate the spatio-temporal delivery of proper signalling based on the biological mechanisms of the different events that occur in the host microenvironment. This review describes the current state of the different signal cues used in wound healing and skin regeneration, and their combination with biomaterial supports to create instructive microenvironments for wound healing. (C) 2018 Elsevier B.V. All rights reserved.
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