Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 129, Issue -, Pages 169-193Publisher
ELSEVIER
DOI: 10.1016/j.addr.2018.02.008
Keywords
Drug delivery; On-demand delivery; Responsive polymers; Stimuli responsive
Categories
Funding
- Government of Maharashtra (INDIA), Postgraduate Scholarship, EBC-2012/ C [164/Edn-1]
- European Regional Development Fund together with Science Foundation Ireland under Ireland's European Structural and Investment Fund [13/RC/2073]
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Non-communicable diseases including cancer, cardiovascular disease, diabetes, and neuropathy are chronic in nature. Treatment of these diseases with traditional delivery systems is limited due to lack of site-specificity, non-spatiotemporal release and insufficient doses. Numerous responsive delivery systems which respond to both physiological and external stimuli have been reported in the literature. However, effective strategies incorporating a multifactorial approach are required to control these complex wounds. This can be achieved by fabricating spatiotemporal release systems, multimodal systems or dual/multi-stimuli responsive delivery systems loaded with one or more bioactive components. Critically, these next generation stimuli responsive delivery systems that are at present not feasible are required to treat chronic wounds. This review provides a critical assessment of recent developments in the field of responsive delivery systems, highlighting their limitations and providing a perspective on how these challenges can be overcome. (C) 2018 Elsevier B.V. All rights reserved.
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