Journal
ADVANCES IN NUTRITION
Volume 7, Issue 4, Pages 798S-805SPublisher
OXFORD UNIV PRESS
DOI: 10.3945/an.115.011221
Keywords
immune function; leucine; BCATc; T cells; mTORC1; KIC
Categories
Funding
- NCI NIH HHS [R01 CA098109] Funding Source: Medline
Ask authors/readers for more resources
In connection with the increasing interest in metabolic regulation of the immune response, this review discusses current advances in understanding the role of leucine and leucine metabolism in T lymphocyte (T cell) activation. T cell activation during the development of an immune response depends on metabolic reprogramming to ensure that sufficient nutrients and energy are taken up by the highly proliferating T cells. Leucine has been described as an important essential amino acid and a nutrient signal that activates complex 1 of the mammalian target of rapamycin (mTORC1), which is a critical regulator of T cell proliferation, differentiation, and function. The role of leucine in these processes is further discussed in relation to amino acid transporters, leucine-degrading enzymes, and other metabolites of leucine metabolism. A new model of T cell regulation by leucine is proposed and outlines a chain of events that leads to the activation of mTORC1 in T cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available