Journal
AMERICAN JOURNAL OF CLINICAL NUTRITION
Volume 103, Issue 2, Pages 323-329Publisher
OXFORD UNIV PRESS
DOI: 10.3945/ajcn.115.120170
Keywords
insulin resistance; lipid; probiotic; weight loss; yogurt
Categories
Funding
- School of Life Sciences, University of Nottingham
- Digestive Disease Research Institute
- Tehran University of Medical Sciences
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Background: Despite evidence for the beneficial effects of probiotics and low-fat dairy products; to our knowledge, no study has compared the beneficial effect on weight loss of consuming a pro biotic yogurt (PY) compared with a standard low-fat yogurt (LF) during a hypoenergetic program. Objective: We compared the effect of the PY with LF yogurt consumption on body weight and cardiometabolic risk factors in women during a weight-loss program. Design: Overweight and obese women [body mass index (in kg/m(2)): 27-40; age: 18-50 y) who usually consumed standard LFs were asked to consume either PY or LF every day with their main meals for 12 wk while following a weight-loss program. Results: A total of 89 participants were randomly assigned to one of the 2 intervention groups. Baseline variables were not significantly different between groups. A statistically significant reduction in anthropometric measurements and significant improvements in cardiometabolic risk characteristics were observed over the 12 wk in both groups. However, no significant differences in weight loss and anthropometric measurements were seen between groups after the intervention. Compared with the LF group, the PY group had a greater (mean +/- SD) decrease in total cholesterol (PY = -0.36 +/- 0.10 mmol/L, LF = -0.31 +/- 0.10 mmol/L; P = 0.024), low-density lipoprotein cholesterol (PY = -0.35 +/- 0.10 mmol/L, LF = -0.31 +/- 0.11 mmol/L; P = 0.018), homeostasis model assessment of insulin resistance (PY = 0.55 +/- 0.32, LF = 0.42 +/- 0.20; P = 0.002), 2-h postprandial glucose (PY = 0.61 +/- 0.24 mmol/L, LF = -0.44 +/- 0.19 mmol/L; P < 0.001), and fasting insulin concentration (PY = -1.76 +/- 1.01 mU/mL, LF = 1.32 0.62 mU/mL; P = 0.002), as secondary endpoints after the study. No significant differences were found for fasting plasma glucose, high-density lipoprotein cholesterol, or triglycerides within both groups after the 12 wk. Conclusion: Consumption of PY compared with LF with main meals showed no significant effects on weight loss. However, it may have positive effects on lipid profiles and insulin sensitivity during a weight-loss program. This trial was registered at http://www.irct.ir/ as IRCT201402177754N8.
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