Journal
ACTA BIOMATERIALIA
Volume 73, Issue -, Pages 38-51Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2018.04.006
Keywords
Poly(lactic-co-glycolic acid); Particles; Drug delivery; Theranostics; Imaging
Funding
- Netherlands Organization for Scientific Research (NWO) [VENI 700.10.409]
- European Research Council (ERC) [ERC-2014-StG-336454-CoNQUeST]
- NWO [VENI 863.130.24]
- NWO VIDI [723.012.110]
- NWO-Vici award [918.14.655]
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Nano- and microparticles have increasingly widespread applications in nanomedicine, ranging from drug delivery to imaging. Poly(lactic-co-glycolic acid) (PLGA) particles are the most widely-applied type of particles due to their biocompatibility and biodegradability. Here, we discuss the preparation of PLGA particles, and various modifications to tailor particles for applications in biological systems. We highlight new preparation approaches, including microfluidics and PRINT method, and modifications of PLGA particles resulting in novel or responsive properties, such as Janus or upconversion particles. Finally, we describe how the preparation methods can- and should-be adapted to tailor the properties of particles for the desired biomedical application. Our aim is to enable researchers who work with PLGA particles to better appreciate the effects of the selected preparation procedure on the final properties of the particles and its biological implications. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd.
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