Journal
ACS NANO
Volume 12, Issue 1, Pages 392-401Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b06560
Keywords
thrombus; photoacoustic imaging; nanoparticles; theranostic; antithrombotic
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Funding
- National Research Foundation (NRF) - Ministry of Science, ICT and Future Planning [2017RaA4A1015681]
- Technology Innovation Program - Ministry of Trade, Industry and Energy [10052749]
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A thrombus (blood clot), composed mainly of activated platelets and fibrin, obstructs arteries or veins, leading to various life-threatening diseases. Inspired by the distinctive physicochemical characteristics of thrombi such as abundant fibrin and an elevated level of hydrogen peroxide (H2O2), we developed thrombus-specific theranostic (T-FBM) nanoparticles that could provide H2O2-triggered photoacoustic signal amplification and serve as an antithrombotic nanomedicine. T-FBM nanoparticles were designed to target fibrin-rich thrombi and be activated by H2O2 to generate CO, bubbles to amplify the photoacoustic signal. In the phantom studies, T-FBM nanoparticles showed significant amplification of ultrasound/photoacoustic signals in a H2O2-triggered manner. T-FBM nanoparticles also exerted H2O2-activatable antioxidant, anti-inflammatory, and antiplatelet activities on endothelial cells. In mouse models of carotid arterial injury, T-FBM nanoparticles significantly enhanced the photoacoustic contrast specifically in thrombosed vessels and significantly suppressed thrombus formation. We anticipate that T-FBM nanoparticles hold great translational potential as nano-theranostics for H2O2-associated cardiovascular diseases.
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