Journal
ACS NANO
Volume 12, Issue 5, Pages 4946-4958Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.8b02038
Keywords
radiation/chemotherapy; radio sensitizer; reactive oxygen species; gold-titanium oxide nanoparticles; heterogeneous interface; triple-negative breast cancers
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Funding
- Stanford Small Animal Imaging Facility
- Stanford Radiochemistry Facility
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Nanoparticle-based radio-sensitizers can amplify the effects of radiation therapy on tumor tissue even at relatively low concentrations while reducing the potential side effects to healthy surrounding tissues. In this study, we investigated a hybrid anisotropic nanostructure, composed of gold (Au) and titanium dioxide (TiO2), as a radio-sensitizer for radiation therapy of triple negative breast cancer (TNBC). In contrast to other gold-based radio sensitizers, dumbbell-like Au-TiO2 nanoparticles (DATs) show a synergistic therapeutic effect on radiation therapy, mainly because of strong asymmetric electric coupling between the high atomic number metals and dielectric oxides at their interfaces. The generation of secondary electrons and reactive oxygen species (ROS) from DATs triggered by X-ray irradiation can significantly enhance the radiation effect. After endocytosed by cancer cells, DATs can generate a large amount of ROS under X-ray irradiation, eventually inducing cancer cell apoptosis. Significant tumor growth suppression and overall improvement in survival rate in a TNBC tumor model have been successfully demonstrated under DAT uptake for a radio sensitized radiation therapy.
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