Journal
ACS CHEMICAL NEUROSCIENCE
Volume 9, Issue 3, Pages 401-403Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.8b00069
Keywords
Alzheimer's disease; multitarget-small molecules; selective drugs
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No selective drugs exist, and we have been designing, synthesizing, and evaluating multitarget-directed ligands since the beginning of modern medicinal chemistry, without knowing it, most possibly. The challenge to discover the efficient Multi-Target Small Molecules (MTSMs) for Alzheimer's disease (AD) therapy implies to identify the key combination of biological targets to modulate them, thus including in the design the corresponding pharmacophoric groups able to do it. Universal and polyvalent pharmacophoric groups, able to modulate diverse receptors or enzymatic systems, would simplify the drug discovery process leading to new and more efficient MTSMs for AD.
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