Journal
ACS CHEMICAL NEUROSCIENCE
Volume 9, Issue 9, Pages 2233-2240Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.7b00398
Keywords
Synaptic plasticity; endocannabinoid; acetylcholine; muscarinic receptors; CB1R; TRPVIR; accumbens; fragile X
Funding
- FRAXA Foundation
- NARSAD 2010 Independent Investigator Grant by Brain & Behavior Research Foundation
- Agence Nationale de la Recherche (ANR)
- INSERM
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We investigated how metabotropic acetylcholine receptors control excitatory synaptic plasticity in the mouse nucleus accumbens core. Pharmacological and genetic approaches revealed that M-1 mAChRs (muscarinic acetylcholine receptors) trigger multiple and interacting forms of synaptic plasticity. As previously described in the dorsal striatum, moderate pharmacological activation of M-1 mAChR potentiated postsynaptic NMDARs. The M-1-potentiation of NMDAR masked a previously unknown coincident TRPV1-mediated long-term depression (LTD). In addition, strong pharmacological activation of M-1 mAChR induced canonical retrograde LTD, mediated by presynaptic CBIR. In the fmr1-/y mouse model of Fragile X, we found that CB1R but not TRPV1 M-1-LTD was impaired. Finally, pharmacological blockade of the degradation of anandamide and 2-arachidonylglycerol, the two principal endocannabinoids restored fmr1-/y LTD to wild-type levels. These findings shed new light on the complex influence of acetylcholine on excitatory synapses in the nucleus accumbens core and identify new substrates of the synaptic deficits of Fragile X.
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