Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 5, Pages 4548-4560Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b18648
Keywords
iron oxide nanoparticles; protein corona; biodistribution; nanoparticles degradation; in vivo
Funding
- Fondo Social de la DGA (grupos DGA), Ministerio de la Economia y Competitividad del Gobierno de Espana [SAF2014-54763-C2-2-R, SAF2014-54763-C2-1-R]
- ERC-Starting Grant [239931-NANOPUZZLE]
- European Union's Horizon research and innovation programme under the Marie Sklodowska-Curie grant [660228, 657215]
- Universidad de Zaragoza [JIUZ-2014-CIE-03]
- Ramon y Cajal subprogram [RYC-2014-15512]
- Marie Curie Actions (MSCA) [657215] Funding Source: Marie Curie Actions (MSCA)
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The protein corona formed on the surface of a nanoparticle in a biological medium determines its behavior in vivo. Herein, iron oxide nanoparticles containing the same core and shell, but bearing two different surface coatings, either glucose or poly(ethylene glycol), were evaluated. The nanoparticles' protein adsorption, in vitro degradation, and in vivo biodistribution and biotransformation over four months were investigated. Although both types of nano particles bound similar amounts of proteins in vitro, the differences in the protein corona composition correlated to the nanoparticles biodistribution in vivo. Interestingly, in vitro degradation studies demonstrated faster degradation for nanoparticles fuctionalized with glucose, whereas the in vivo results were opposite with accelerated biodegradation and clearance of the nanoparticles functionalized with poly(ethylene glycol). Therefore, the variation in the degradation rate observed in vivo could be related not only to the molecules attached to the surface, but also with the associated protein corona, as the key role of the adsorbed proteins on the magnetic core degradation has been demonstrated in vitro.
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