Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 27, Pages 22963-22973Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b05363
Keywords
umbilical cord mesenchymal stem cell; plasma membrane; biomimetic nanoparticle; targeted drug delivery; cancer therapy
Funding
- National Basic Research Plan of China [2018YFA0208900]
- National Natural Science Foundation of China [31671023, 31700864, 31571021, 11621505, 81771982]
- Beijing Natural Science Foundation [7174333]
- Key Research Program of Frontier Sciences, CAS [QYZDJ-SSW-SLH022]
- Key Research Program of CAS [KFZD-SW-210]
- National Key R&D Program of China [2017YFF0108600]
Ask authors/readers for more resources
Multiple cell plasma membranes have been utilized for surface functionalization of synthetic nanomaterials and construction of biomimetic drug delivery systems for cancer treatment. The natural characters and facile isolation of original cells facilitate the biomedical applications of plasma membranes in functionalizing nanocarriers. Human umbilical cord-derived mesenchymal stem cells (MSCs) have been identified to show tropism toward malignant lesions and have great advantages in ease of acquisition, low immunogenicity, and high proliferative ability. Here, we developed a poly(lactic-co-glycolic acid) (PLGA) nanoparticle with a layer of plasma membrane from umbilical cord MSC coating on the surface for tumor-targeted delivery of chemotherapy. Functionalization of MSC plasma membrane significantly enhanced the cellular uptake efficiency of PLGA nanoparticles, the tumor cell killing efficacy of PLGA-encapsulated doxorubicin, and most importantly the tumor-targeting and accumulation of the nanoparticles. As a result, this MSC-mimicking nanoformulation led to remarkable tumor growth inhibition and induced obvious apoptosis within tumor lesions. This study for the first time demonstrated the great potential of umbilical cord MSC plasma membranes in functionalizing nanocarriers with inherent tumor-homing features and the high feasibility of such biomimetic nanoformulations in cancer therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available