Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 25, Pages 21198-21205Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b06758
Keywords
hyperbranched polyphosphoester; pH-sensitive; photodynamic therapy; activatable PDT; pancreatic cancer
Funding
- National Key R&D Program of China [2017YFA0205601]
- Program for Guangdong Introducing Innovative and Enterpreneurial Teams [2017ZT07S054]
- National Natural Science Foundation of China [51473043, 51773067]
- Natural Science Foundation for Distinguished Young Scholars of Guangdong Province [2017B030306002]
- Fundamental Research Funds for the Central Universities
Ask authors/readers for more resources
Nanocarrier-mediated photodynamic therapy (PDT), which involves the systemic delivery of photo sensitizers (PSs) into tumor tissue and tumor cells, has emerged as an attractive treatment for cancer. However, insufficient PS release limits intracellular cytotoxic reactive oxygen species (ROS) generation, which has become a major obstacle to improving the PDT therapeutic efficacy. Herein, a novel hyperbranched polyphosphoester (hbPPE) containing numerous acetal bonds (S-hbPPE/Ce6) was explored as a chlorin e6 (Ce6) nanocarrier for PDT. S-hbPPE/Ce6 with a branched topological structure efficiently encapsulated Ce6 and then significantly enhanced its internalization by tumor cells. Subsequently, the endo-/lysosomal acid microenvironment rapidly cleaved the acetal linkage of S-hbPPE and destroyed the nanostructure of S-hbPPE/Ce6, resulting in increased Ce6 release and obviously elevated the intracellular ROS generation under illumination. Therefore, treatment with S-hbPPE/Ce6 noticeably enhanced the PDT therapeutic efficacy, indicating that such a pH-sensitive hbPPE nanocarrier has great potential to improve the PDT therapeutic efficacy for cancer therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available