Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 25, Pages 21091-21102Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b02141
Keywords
growth factors; polycaprolactone; delivery system; tissue engineering; miniature pig
Funding
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health Welfare, Korea [HI13C1596, HI15C0607]
- Basic Science Research Program through the National Research Foundation (NRF) of Korea - Ministry of Science, ICT, and Future Planning [NRF-2015R1A5A2008833]
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Sustained release of bioactive molecules from delivery systems is a common strategy for ensuring their prolonged bioactivity and for minimizing safety issues. However, residual toxic reagents, the use of harsh organic solvents, and complex fabrication procedures in conventional delivery systems are considered enormous impediments toward clinical use. Herein, we describe bone morphogenetic protein-2 (BMP-2)-immobilized porous polycaprolactone particles with unique leaf-stacked structures (LSS particles) prepared using clinically feasible materials and procedures. The BMP-2 immobilized in these LSS particles is continuously released up to 36 days to provide an appropriate environment for osteogenic differentiation of human periosteum-derived cells and new bone formation. Thus, the leaf-stacked structures of these LSS particles provide a simple but clinically applicable platform for effectively delivering a variety of bioactive molecules, such as growth factors, hormones, cytokines, peptides, etc.
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