Synthesizing Pickering Nanoemulsions by Vapor Condensation

Nanoparticle-stabilized (Pickering) emulsions are widely used in applications such as cosmetics, drug delivery, membranes, and material synthesis. However, formulating Pickering nanoemulsions remains a significant challenge. Herein, we show that Pickering nanoemulsions can be obtained in a single step even at very low nanoparticle loadings (0.2 wt %) by condensing water vapor on a nanoparticle-infused subcooled oil that spreads on water. Droplet nuclei spontaneously submerge within the oil after nucleating at the oil air interface, resulting in the suppression of droplet growth by diffusion, and subsequently coalesce to larger sizes until their growth is curtailed by nanoparticle adsorption. The average nanoemulsion size is governed by the competition between nanoparticle adsorption kinetics and droplet growth dynamics, which are in turn a function of nanoparticle size, concentration, and condensation time. Controlling such factors can lead to the formation of highly monodisperse nanoemulsions. Emulsion formation via condensation is a fast, scalable, energy-efficient process that can be adapted for a wide variety of emulsion-based applications in biology, chemistry, and materials science.