Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 5, Pages 4910-4920Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b14193
Keywords
rare-earth-doped upconversion nanoparticles; pillararene; host-guest complexation; upconversion luminescence imaging/magnetic resonance imaging; drug release
Funding
- National Key R&D Program of China [2016YFE0114800]
- National Natural Science Foundation of China [21571125]
- National Basic Research Program of China [2016YFA0201600]
- Concordia University
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Exploring novel drug delivery systems with good stability and new structure to integrate pillararene and upconversion nanoparticles (UCNPs) into one system continues to-be an important challenge. Herein, we report a novel preparation of a supramolecular upconversion nanosystem via the host-guest complexation based on carboxylate-based pillar[5]arene (WP5) and 15-carboxy-N,N,N-trialkylpen-tadecan-1-ammonium bromide (1)-functionalized UCNPs to produce WP5 superset of 1-UCNPs that can be loaded with the chemotherapeutic drug doxorubicin (DOX). Importantly, the WP5 on the surface of the drug-loaded nanosystem can be efficiently protonated under acidic conditions, resulting in the collapse of the nanosystem and drug release. Moreover, cellular uptake confirms that the nanosystem can enter human cervical cancer (HeLa) cells, resulting in drug accumulation in the cells. More importantly, cytotoxicity experiments demonstrated the excellent biocompatibility of WPS superset of 1-UCNPs without loading DOX and that the nanosystem DOX-WPS superset of 1-UCNPs exhibited an ability of killing HeLa cells effectively. We also investigated magnetic resonance imaging and upconversion luminescence imaging, which may be employed as visual imaging agents in cancer diagnosis and treatment. Thus, in the present work, we show a simple yet powerful strategy to combine UCNPs and pillar[5]arene to produce a unified nanosystem for dual-mode bioimaging-guided therapeutic applications.
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