Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 23, Pages 19514-19522Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b05706
Keywords
optical imaging; near-infrared light (NIR); upconverting persistent luminescent nanophosphors (UPLNs); tumor-associated macrophages; cell therapy
Funding
- National Key Research and Development Program of China [2017YFA0205104]
- National Natural Science Foundation of China [51373117, 51573128, 81771970]
- Tianjin Natural Science Foundation [15JCQNJC03100]
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Optical imaging for biological applications is in need of more sensitive tool. Persistent luminescent nanophosphors enable highly sensitive in vivo optical detection and almost completely avoid tissue autofluorescence. Nevertheless, the actual persistent luminescent nanophosphors necessitate ex vivo activation before systemic operation, which severely restricted the use of long-term imaging in vivo. Hence, we introduced a novel generation of optical nanophosphors, based on (Zn2SiO4:Mn):Y3+, Yb3+, Tm3+ upconverting persistent luminescent nanophosphors; these nanophosphors can be excited in vivo through living tissues by highly penetrating near-infrared light. We can trace labeled tumor therapeutic macrophages in vivo after endocytosing these nanophosphors in vitro and follow macrophages biodistribution by a simple whole animal optical detection. These nanophosphors will open novel potentials for cell therapy research and for a variety of applications in diagnosis in vivo.
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