Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 13, Pages 10601-10606Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b00207
Keywords
gold nanoclusters; radiotherapy; radiosensitizer; GSH depletion; regulation of the cell cycle
Funding
- National Natural Science Foundation of China [21673037, 81571805]
- Natural Science Foundation of Jiangsu Province [BK20170078]
- Innovative and Entrepreneurial Talent Recruitment Program of Jiangsu Province
- Six Talents Peak Project in Jiangsu Province [2015-SWYY-003]
- Fundamental Research Funds for the Central Universities
- Postgraduate Research&Practice Innovation Program of Jiangsu Province [KYCX17_0155, KYCX17_0157]
- Scientific Research Foundation of Graduate School of Southeast University [YBJJ1777, YBJJ1778]
- Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry
- University of Michigan
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The therapeutic performance of cancer radiotherapy is often limited by the overexpression of glutathione (GSH) in tumors and low radiation sensitivity of cancerous cells. To address these issues, the facilely prepared histidine-capped gold nanoclusters (Au NCs@His) were adopted as a radiosensitizer with a high sensitization enhancement ratio of similar to 1.54. On one hand, Au NCs@His can inherit the local radiation enhancement property of gold-based materials (external regulation); on the other hand, Au NCs@His can decrease the intracellular GSH level, thus preventing the generated reactive oxygen species (ROS) from being consumed by GSH, and arrest the cells at the radiosensitive G2/M phase (internal regulation).
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