Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 4, Pages 4131-4139Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b17481
Keywords
stimuli responsive; drug delivery; gold nanoshells; light triggered; biodegradable polymers; poly(ethylene glycol); polycaprolactone
Funding
- European Union's-Seventh Framework Programme (FP7) [631280]
- Russell Berrie department
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Light responsive materials play an important role in many biomedical applications. Despite the great potential, commonly available systems are limited by their toxicity and lack of biodegradability. Here, an efficient light triggered system from safe, biodegradable star-poly(ethylene glycol) (star-PEG) and poly(epsilon-caprolactone) (PCL) with varying: melting points controlled by the length of the CL segments is described. When incorporated with gold nano-shells (GNS) and exposed to near-infrared (NIR) irradiation, matrices temporarily disengage, thus allowing efficient on-demand healing and drug release. The responsiveness of this system to light, with its tailorable physical and healing properties, biocompatibility, biodegradability, and the capability to incorporate drugs and on-demand drug release are all desirable traits for numerous clinical applications.
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