Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 3, Pages 2338-2346Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b16595
Keywords
nanomotor; light responsive; motion control; chemotaxis; photothermal cancer therapy
Funding
- Nano.Material Technology Development Program [2017M3A7B8065278]
- Basic Science Research Program of the National Research Foundation (NRF) - Ministry of Science, ICT & Future Planning, Korea [2017R1E1A1A03070458]
- World Class 300 Project (R&D) of the Small and Medium Business Administration (SMBA), Korea [S2482887]
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Machines have greatly contributed to the human civilization, enabling tasks beyond our capacities for improved quality of life. Recently, the progress in nanotechnology has triggered to build a miniaturized machine of nanoscale. In this context, synthetic nanomotors have gained considerable interest because of their great promise for diverse applications. Currently, the movement control of these nanomotors has been widely investigated using various stimuli. Here, we demonstrate near -infrared (NIR) light controlled on/off motion of stomatocyte nanomotors powered by the conversion of hydrogen peroxide. The nanomotors encapsulating naphthalocyanine (NC) are aggregated or separated (collective motion) with or without near-IR light illumination, resulting in the well-controlled movement. Remarkably, the nanomotors can move directionally toward hydrogen peroxide released from cancer cells and photothermally ablate the cancer cells. Taken together, our stomatocyte nanomotor systems can be effectively harnessed for autonomous photothermal cancer therapy.
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