Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 17, Pages 14475-14482Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b02080
Keywords
nanoscale covalent organic polymers; pH-responsive; drug delivery; photodynamic chemotherapy; tumor
Funding
- National Key Research Programs of China from MOST [2016YFA0201200]
- National Natural Science Foundation of China [51525203, 51761145041]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
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Covalent organic polymers (COPs) are a promising class of cross-linked polymeric networks and porous structures composed of covalent organic molecules that attract extensive attention. Despite increasing interest in applying COPs for applications in nanomedicine, the pH-sensitive COPs that are able to sensitively respond to the slightly acidic tumor microenvironment for tumor-specific drug delivery and therapy remain to be explored to our best knowledge. Herein, a new style of pH-responsive COPs were prepared using acryloyl meso-tetra(p-hydroxyphenyl) porphine (acryloyl-THPP) to react with 4,4'-trimethylene dipiperidine to form the pH responsive cross-linked biodegradable beta-amino esters (BAEs). Amine-modified poly(ethylene glycol) (PEG) was then introduced to terminate the reaction and form the PEG shell. The formulated pH-responsive THPP-BAE-PEG COPs can be utilized to encapsulate anticancer drug doxorubicin (DOX) due to their porous structure. Upon intravenous injection, such DOX-loaded COPs show a prolonged blood circulation as well as an efficient tumor accumulation. Along with the pH-triggered drug release for chemotherapy, the singlet oxygen produced by THPP under light exposure for photodynamic therapy would further endow us a combined treatment strategy, which offers synergistic antitumor effects in our in vivo tumor model experiments. Our study illustrates that COPs fabricated with tumor microenvironment responsive linkers may be a promising type of materials for applications in cancer nanomedicine.
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