Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 10, Pages 8436-8442Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b17219
Keywords
graphdiyne; doxorubicin; drug delivery; photothermal therapy; chemotherapy; combination treatment
Funding
- National Nature Science Foundation of China [21790051]
- National Key Research and Development Project of China [2016YFA0200104, 2016YFA0201600]
- Science Fund for Creative Research Groups of the National Natural Science Foundation of China [11621505]
- CAS Key Research Program for Frontier Sciences [QYZDJ-SSW-SLH022]
- CAS interdisciplinary innovation team
- National Science Fund for Distinguished Young Scholars [11425520]
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Nowadays, two-dimensional (2D) materials have attracted extensive attention as cancer drug delivery platforms owing to their unparalleled physicochemical properties and superior specific surface area. Graphdiyne (GDY) is a novel 2D carbon material. Compared with graphene, GDY not only has benzene rings composed of sp(2)-hybridized carbon atoms but also has acetylene units composed of sp-hybridized carbon atoms; therefore, it possesses multiple conjugated electronic structures. Herein, we used doxorubicin (DOX) as a model drug to develop a GDY nanosheet-based drug delivery platform for a photothermal/chemotherapy combination in living mice. With a high photo thermal conversion ability and drug loading efficiency, GDY/DOX under 808 nm laser irradiation showed a much higher cancer inhibition rate compared with solo therapy both in vitro and in vivo. Furthermore, GDY exhibited great biocompatibility and no obvious side effects, as shown by histopathological examination and serum biochemical analysis. For the first time, our work demonstrated a successful example of GDY for efficient photothermal/chemotherapy and suggests both safety and great promise for GDY in cancer treatment.
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