Journal
RSC ADVANCES
Volume 6, Issue 83, Pages 80055-80058Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra11408c
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Funding
- National Natural Science Foundation of China [21172169, 21572154]
- National Basic Research Project [2014CB932201]
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In this study, a concise and atom-economical TfOH-mediated [2 + 2 + 2] cycloaddition of ynamides with two discrete nitriles is developed to synthesize multi-substituted 4-aminopyrimidine. A variety of functional groups and sterically and electronically diverse reaction partners are tolerated. The products were obtained in good to excellent yields.
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