Journal
AAPS PHARMSCITECH
Volume 19, Issue 5, Pages 2023-2040Publisher
SPRINGER
DOI: 10.1208/s12249-018-1069-1
Keywords
lyotropic liquid crystal; glyceryl monooleate; phytantriol; guest molecules; characterization methods
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Funding
- National Natural Science Foundation of China [81274099]
- Anhui Provincial Talents Project for youth in Universities [gxyq2018025]
- Anhui Provincial Natural Science Foundation [1408085QH183]
- Exploratory Research Projects of Anhui University of Chinese Medicine [2016ts066]
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Liquid crystals (LCs) are conventionally divided into thermotropic or lyotropic, based on the organization and sequence of the controlled molecular system. Lipid-based lyotropic liquid crystal (LLC), such as lamellar (L alpha), bicontinuous cubic (Q(II)), or hexagonal (H-II) phases, have attracted wide interest in the last few decades due to their practical potential in diverse applications and notable structural complexity. Various guest molecules, such as biopharmaceuticals, chemicals, and additives, can be solubilized in either aqueous or oily phase. And the LLC microstructure can be altered to affect the rate of drug release eventually. To utilize these microstructural variations to adjust the drug release in drug delivery system (DDS), it is crucial to understand the structure variations of the LLC caused by different types of guest molecules. Therefore, in this article, we review the effect of guest molecules on lipid-based LLC microstructures. In particular, we focus on the different characterization methods to evaluate this change caused by guest substances, such as polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), self-diffusion nuclear magnetic resonance (SD-NMR), and so on.
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