Journal
SLAS DISCOVERY
Volume 22, Issue 9, Pages 1162-1167Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/2472555217724437
Keywords
earthworm; extract; asymmetric aldol reaction; biocatalysis; large-scale synthesis
Funding
- National Natural Science Foundation of China [21472152, 21672174]
- Basic and Frontier Research Project of Chongqing [cstc2015jcyjBX0106]
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A crude extract from earthworms was used as an environmentally friendly and easily accessible biocatalyst for asymmetric direct aldol reactions. The -hydroxy carbonyl compounds could be prepared in yields of up to 94%, with ee values of up to 98% and dr of up to >99:1. A wide range of substrates could participate in the reaction. This earthworm catalyst was also efficient in the large-scale reaction, providing product in excellent yield and good selectivity. The protocol as an example gives inspiration for the development of sustainable catalysts from nature, which also provides a potential possibility for application of earthworm catalyst in industrial production.
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