4.6 Article

Folate Receptor-Targeted Theranostic Nanoconstruct for Surface-Enhanced Raman Scattering Imaging and Photodynamic Therapy

Journal

ACS OMEGA
Volume 1, Issue 4, Pages 730-735

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acsomega.6b00176

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Funding

  1. Defense Advanced Research Projects Agency [HR0011-13-2-0003]
  2. Duke University Exploratory Research Funds

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We report the synthesis of a folate receptor (FR)-targeted theranostic nanocomposite for surface-enhanced Raman scattering (SERS) imaging and photodynamic therapy (PDT). FR-specific SERS detection and PDT are demonstrated in vitro using two FR-positive cancer cell lines and one FR-negative cancer cell lines.

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