Journal
NEUROBIOLOGY OF STRESS
Volume 4, Issue -, Pages 15-22Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ynstr.2016.03.003
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Funding
- Brain and behavior research foundation NARSAD young investigator award
- National Center for Complementary and Integrative Health (NCCIH) [P50 AT008661-01]
- Office of Dietary Supplements (ODS)
- [R01MH104559]
- [R01MH090264]
- [R21MH099562]
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There is growing evidence of a relationship between inflammation and psychiatric illness. In particular, the cytokine Interleukin-6 (IL-6) has been linked to stress-related disorders such as depression and anxiety. Here we discuss evidence from preclinical and clinical studies examining the role of IL-6 in mood disorders. We focus on the functional role of peripheral and central release of IL-6 on the development of stress susceptibility and depression-associated behavior. By examining the contribution of both peripheral and central IL-6 to manifestations of stress-related symptomatology, we hope to broaden the way the field thinks about diagnosing and treating mood disorders. (C) 2016 Published by Elsevier Inc.
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