Journal
NATURE BIOMEDICAL ENGINEERING
Volume 1, Issue 12, Pages 993-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41551-017-0167-9
Keywords
-
Categories
Funding
- National Institutes of Health National Institute of Biomedical Imaging and Bioengineering [EB018378-01, EB015169-02]
- Singapore University of Technology and Design-Massachusetts Institute of Technology International Design Centre [IDG31400106]
- Singapore Ministry of Education [MOE2014-T2-2-145]
Ask authors/readers for more resources
The identification and molecular profiling of early metastases remains a major challenge in cancer diagnostics and therapy. Most in vivo imaging methods fail to detect small cancerous lesions, a problem that is compounded by the distinct physical and biological barriers associated with different metastatic niches. Here, we show that intravenously injected rare-earth-doped albumin-encapsulated nanoparticles emitting short-wave infrared light (SWIR) can detect targeted metastatic lesions in vivo, allowing for the longitudinal tracking of multi-organ metastases. In a murine model of human breast cancer, the nanoprobes enabled whole-body SWIR detection of adrenal-gland microlesions and bone lesions that were undetectable via contrast-enhanced magnetic resonance imaging as early as three and five weeks post-inoculation, respectively. Whole-body SWIR imaging of nanoprobes functionalized to differentially target distinct metastatic sites and administered to a biomimetic murine model of human breast cancer resolved multi-organ metastases that showed varied molecular profiles in the lungs, adrenal glands and bones. Real-time surveillance of lesions in multiple organs should facilitate pre- and post-therapy monitoring in preclinical settings.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available