Journal
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Volume 57, Issue 13, Pages 5285-5287Publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.16-20557
Keywords
neuropathic; keratomileusis; CNS; migraine; dry eye; referred pain
Categories
Funding
- National Institutes of Health, Bethesda, Maryland, United States [5K24NS064050-09, 4R01NS075018-05, 5R01NS073997-06, 5R01NS095655-02, 5R21CA185870-02]
- Migraine Research Foundation (New York, NY, USA)
- Mayday Foundation (New York, NY, USA)
- Boston EyePain Foundation (Boston, MA, USA)
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The cornea is supplied principally by the ophthalmic branch of the trigeminal nerve and is the most densely innervated organ in the human body. Under normal conditions, the corneal nerve terminals incorporate sensors that monitor the thickness and integrity of the tear film, which are essential for meaningful vision. A disrupted tear film or direct noxious stimulation of these corneal nerves can produce discomfort or pain limited to the affected surface. Damage to these nerves can sometimes lead to a chronic neuropathic condition, where pain persists months following the initial insult, long after the nerves appear to have healed in the cornea itself following treatment. Neuropathic pain appears to persist indefinitely in a few patients.
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