Journal
BIRTH DEFECTS RESEARCH
Volume 109, Issue 19, Pages 1519-1539Publisher
WILEY
DOI: 10.1002/bdr2.1089
Keywords
lung development; postnatal maturation; pediatric drug development; respiratory function; lung morphology
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The purpose of this review is to give an outline of respiratory tract morphological and functional development with an emphasis on perinatal and postnatal maturational processes. In view of the rising need for qualitative and quantitative data for the development of pediatric pharmaceuticals, a comparison of the human situation to experimental animal models is made, and functional data as well as suitable models for human airway diseases and functional testing are presented. Birth Defects Research 109:1519-1539, 2017. (c) 2017 Wiley Periodicals, Inc.
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