Journal
NATURE REVIEWS CANCER
Volume 16, Issue 10, Pages 650-662Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc.2016.81
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Funding
- Cancer Research UK [C596/A10419]
- European Research Council [322842-METABOp53]
- Cancer Research UK [18274] Funding Source: researchfish
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The non-essential amino acid serine supports several metabolic processes that are crucial for the growth and survival of proliferating cells, including protein, amino acid and glutathione synthesis. As an important one-carbon donor to the folate cycle, serine contributes to nucleotide synthesis, methylation reactions and the generation of NADPH for antioxidant defence. Many cancer cells are highly dependent on serine, a trait that provides several novel therapeutic opportunities, either through the inhibition of de novo serine synthesis or by limiting the availability or uptake of exogenous serine.
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