Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/ijms17101771
Keywords
melatonin; sarcopenia; frailty; skeletal muscle; aging
Funding
- Salvador de Madariaga Programme from the Ministerio de Educacion, Cultura y Deportes (Instituto de Salud Carlos III) [FISS-13-RD12/0043/0030, FISS-11-01381, FISS-14-PI13/02741]
- Plan de Ciencia, Tecnologia e Innovacion (PCTI) del Principado de Asturias [GRUPIN14-071]
- Fondo Europeo de Desarrollo Regional (FEDER) funds
Ask authors/readers for more resources
Considering the increased speed at which the world population is aging, sarcopenia could become an epidemic in this century. This condition currently has no means of prevention or treatment. Melatonin is a highly effective and ubiquitously acting antioxidant and free radical scavenger that is normally produced in all organisms. This molecule has been implicated in a huge number of biological processes, from anticonvulsant properties in children to protective effects on the lung in chronic obstructive pulmonary disease. In this review, we summarize the data which suggest that melatonin may be beneficial in attenuating, reducing or preventing each of the symptoms that characterize sarcopenia. The findings are not limited to sarcopenia, but also apply to osteoporosis-related sarcopenia and to age-related neuromuscular junction dysfunction. Since melatonin has a high safety profile and is drastically reduced in advanced age, its potential utility in the treatment of sarcopenic patients and related dysfunctions should be considered.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available