Journal
WESTERN JOURNAL OF EMERGENCY MEDICINE
Volume 17, Issue 3, Pages 290-294Publisher
WESTJEM
DOI: 10.5811/westjem.2016.2.29519
Keywords
Synthetic cannabinoids; MAB-CHMINACA toxicity; CB1 CB2 receptor agonism; Schedule 1 Controlled Substance Act; Delta-9 Tetrahydrocannabinol
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Synthetic cannabinoid use has risen at alarming rates. This case series describes 11 patients exposed to the synthetic cannabinoid, MAB-CHMINACA who presented to an emergency department with life-threatening toxicity including obtundation, severe agitation, seizures and death. All patients required sedatives for agitation, nine required endotracheal intubation, three experienced seizures, and one developed hyperthermia. One developed anoxic brain injury, rhabdomyolysis and died. A significant number were pediatric patients. The mainstay of treatment was aggressive sedation and respiratory support. Synthetic cannabinoids pose a major public health risk. Emergency physicians must be aware of their clinical presentation, diagnosis and treatment.
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