4.6 Article

Gallium-catalyzed reductive lactonization of γ-keto acids with a hydrosilane

Journal

RSC ADVANCES
Volume 6, Issue 85, Pages 81763-81766

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra19286f

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Funding

  1. JSPS KAKENHI Grant [JP25410120]

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Described herein is the GaCl3-catalyzed lactonization of gamma-keto carboxylic acids in the presence of PhSiH3 leading to the direct preparation of gamma-lactone derivatives. This reducing system showed a relatively wide functional group tolerance.

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