Journal
JOURNAL OF ORTHOPAEDIC TRANSLATION
Volume 10, Issue -, Pages 28-35Publisher
ELSEVIER
DOI: 10.1016/j.jot.2017.04.002
Keywords
ageing; bone; inflammation; macrophages; stem cells
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Funding
- NIAMS NIH HHS [R01 AR063717, R01 AR055650] Funding Source: Medline
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Bone healing involves complex biological pathways and interactions among various cell types and microenvironments. Among them, the monocyte-macrophage-osteoclast lineage and the mesenchymal stem cell-osteoblast lineage are critical, in addition to an initial inflammatory microenvironment. These cellular interactions induce the necessary inflammatory milieu and provide the cells for bone regeneration and immune modulation. Increasing age is accompanied with a rise in the basal state of inflammation, potentially impairing osteogenesis. The translational potential of this article: Translational research has shown multiple interactions between inflammation, ageing, and bone regeneration. This review presents recent, relevant considerations regarding the effects of inflammation and ageing on bone healing. (C) 2017 The Authors. Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.
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