Journal
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
Volume 6, Issue 4, Pages 393-398Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jpids/piw066
Keywords
diagnostic microbiology; encephalitis; meningitis; metagenomic next-generation sequencing; neurobrucellosis
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Funding
- National Institutes of Health [R01-HL105704, R21-AI120977]
- Abbott Laboratories, Inc.
- California Institute to Advance Precision Medicine
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A diagnosis of brucellosis can be difficult because routine culture and serological methods exhibit variable sensitivity and specificity. We present the use of a metagenomic next-generation sequencing assay to diagnose a case of neurobrucellosis from cerebrospinal fluid, resulting in the institution of appropriate antibiotic treatment and a favorable clinical outcome.
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