Journal
OPEN FORUM INFECTIOUS DISEASES
Volume 4, Issue 1, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofx022
Keywords
immunity; malaria; sex; T regulatory cells; vaccines
Categories
Funding
- National Institutes of Health [5P01HD059454-07, 2R01AI093615-06, 5K24AI113002-03, 5T32AI060530-10]
- Infectious Diseases Society of America Education and Research Foundation
- National Foundation for Infectious Diseases
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Sex differences in the immune response and in infectious disease susceptibility have been well described, although the mechanisms underlying these differences remain incompletely understood. We evaluated the frequency of cord blood CD4 T cell subsets in a highly malaria-exposed birth cohort of mother-infant pairs in Uganda by sex. We found that frequencies of cord blood regulatory T cell ([T-reg] CD4(+) CD25(+) FoxP3(+) CD127(lo/-)) differed by infant sex, with significantly lower frequencies of T-regs in female than in male neonates (P = .006). When stratified by in utero malaria exposure status, this difference was observed in the exposed, but not in the unexposed infants.
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