4.4 Article

Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab

Journal

OPEN FORUM INFECTIOUS DISEASES
Volume 4, Issue 3, Pages -

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofx174

Keywords

acute liver failure; echovirus; metagenomic next-generation sequencing; rituximab

Funding

  1. NIAID NIH HHS [T32 AI007044] Funding Source: Medline
  2. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI007044] Funding Source: NIH RePORTER

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We describe a case of fatal acute liver failure due to echovirus 9 in the setting of persistent B-cell depletion and hypogammaglobulinemia 3 years after rituximab therapy. Metagenomic next-generation sequencing further specified the etiologic agent. Early recognition may provide an opportunity for interventions including intravenous immunoglobulin and liver transplantation.

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