Journal
OPEN FORUM INFECTIOUS DISEASES
Volume 4, Issue 3, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofx174
Keywords
acute liver failure; echovirus; metagenomic next-generation sequencing; rituximab
Categories
Funding
- NIAID NIH HHS [T32 AI007044] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI007044] Funding Source: NIH RePORTER
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We describe a case of fatal acute liver failure due to echovirus 9 in the setting of persistent B-cell depletion and hypogammaglobulinemia 3 years after rituximab therapy. Metagenomic next-generation sequencing further specified the etiologic agent. Early recognition may provide an opportunity for interventions including intravenous immunoglobulin and liver transplantation.
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