Journal
EUROSURVEILLANCE
Volume 20, Issue 41, Pages 13-17Publisher
EUR CENTRE DIS PREVENTION & CONTROL
DOI: 10.2807/1560-7917.ES.2015.20.41.30042
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Funding
- Clinical Research Institute, Seoul National University Hospital, South Korea [20151980]
- US National Institutes of Health [HHSN272201400006C]
- Health and Medical Research Fund, Food and Health Bureau, Government of Hong Kong Special Administrative Region
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Plaque reduction neutralisation tests (PRNT), micro-neutralisation (MN), Middle East respiratory syndrome (MERS)-spike pseudoparticle neutralisation (ppNT) and MERS S1-enzyme-linked immunosorbent assay (ELISA) antibody titres were compared using 95 sera from 17 patients with MERS, collected two to 46 days after symptom onset. Neutralisation tests correlated well with each other and moderately well with S1 ELISA. Moreover to compare antigenic similarity of genetically diverse MERS-CoV clades, the response of four sera from two patients sampled at two time periods during the course of illness were tested by 90% PRNT. Genetically diverse MERS-CoV clades were anti-genically homogenous.
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