Journal
NPJ GENOMIC MEDICINE
Volume 2, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41525-017-0038-z
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Funding
- Lundbeck Foundation [R191-2015-1515]
- Danish Cancer Society [R124-A7869]
- Sapere Aude Program of the Independent Research Fund Denmark \ Medical Sciences [12-126439]
- Lundbeck Foundation [R191-2015-1515] Funding Source: researchfish
- Novo Nordisk Fonden [NNF16OC0019874] Funding Source: researchfish
- The Danish Cancer Society [R124-A7869] Funding Source: researchfish
- Villum Fonden [00013393] Funding Source: researchfish
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The functions and biomarker potential of circular RNAs (circRNAs) in various cancer types are a rising field of study, as emerging evidence relates circRNAs to tumorigenesis. Here, we profiled the expression of circRNAs in 457 tumors from patients with non-muscle-invasive bladder cancer (NMIBC). We show that a set of highly expressed circRNAs have conserved core splice sites, are associated with Alu repeats, and enriched with Synonymous Constraint Elements as well as microRNA target sites. We identified 113 abundant circRNAs that are differentially expressed between high and low-risk tumor subtypes. Analysis of progression-free survival revealed 13 circRNAs, among them circHIPK3 and circCDYL, where expression correlated with progression independently of the linear transcript and the host gene. In summary, our results demonstrate that abundant circRNAs possess multiple biological features, distinguishing them from low-expressed circRNAs and non-circularized exons, and suggest that circRNAs might serve as a new class of prognostic biomarkers in NMIBC.
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