Journal
PHARMACEUTICS
Volume 9, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics9040054
Keywords
cocrystal preparation; polyvinyl pyrrolidone; carbamazepine; nicotinamide; saccharin
Categories
Funding
- Science and Technology Project of Hebei Province [16211505]
- Natural Science Foundation of Hebei Province Youth Fund [E2016209327]
- Doctoral Research Fund of North China University of Science and Technology [28405399]
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In this study, we attempted to prepare carbamazepine (CBZ) cocrystal through the solution method in ethanol-water solvent mixture (volume ratio 1:1) and polyvinyl pyrrolidone (PVP) solution. Nicotinamide (NIC) and saccharin (SAC) were selected as cocrystal coformers. Cocrystal screening products were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), and Powder X-ray Diffraction (PXRD) techniques. Characterization results show that in ethanol-water solvent mixture, pure CBZ-NIC cocrystal can be prepared, while CBZ-SAC cocrystal cannot be obtained. The addition of PVP can inhibit CBZ-NIC cocrystal formation and facilitate CBZ-SAC cocrystal formation.
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