4.5 Article

Assessing the risk of observing multiple generations of Middle East respiratory syndrome (MERS) cases given an imported case

Journal

EUROSURVEILLANCE
Volume 20, Issue 27, Pages 6-11

Publisher

EUR CENTRE DIS PREVENTION & CONTROL
DOI: 10.2807/1560-7917.ES2015.20.27.21181

Keywords

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Funding

  1. Japan Society for the Promotion of Science (JSPS) KAKENHI [26670308, 26700028]
  2. Japan Agency for Medical Research and Development
  3. Japan Science and Technology Agency (JST) CREST program
  4. RISTEX program for Science of Science, Technology and Innovation Policy
  5. Division of International Epidemiology and Population Studies, Fogarty International Center, United States National Institutes of Health
  6. Office of Pandemics and Emerging Threats at the United States Department of Health and Human Services
  7. NSF, joint NSF-NIH-USDA Ecology and Evolution of Infectious Diseases programme [1414374]
  8. United Kingdom Biotechnology and Biological Sciences Research Council grant [BB/M008894/1]
  9. NSF-IIS Grant [1518939]
  10. BBSRC [BB/M008894/1] Funding Source: UKRI

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To guide risk assessment, expected numbers of cases and generations were estimated, assuming a case importation of Middle East respiratory syndrome (MERS). Our analysis of 36 importation events yielded the risk of observing secondary transmission events at 22.7% (95% confidence interval: 19.3-25.1). The risks of observing generations 2, 3 and 4 were estimated at 10.5%, 6.1% and 3.9%, respectively. Countries at risk should be ready for highly variable outcomes following an importation of MERS.

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