Journal
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
Volume 15, Issue -, Pages 307-319Publisher
ELSEVIER
DOI: 10.1016/j.csbj.2017.03.004
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Funding
- Swiss National Science Foundation [200020_157153]
- Swiss National Science Foundation (SNF) [200020_157153] Funding Source: Swiss National Science Foundation (SNF)
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Post-translational modifications (PTMs) occur in almost all proteins and play an important role in numerous biological processes by significantly affecting proteins' structure and dynamics. Several computational approaches have been developed to study PTMs (e,g, phosphorylation, sumoylation or palmitoylation) showing the importance of these techniques in predicting modified sites that can be further investigated with experimental approaches. In this review, we summarize some of the available online platforms and their contribution in the study of PTMs. Moreover, we discuss the emerging capabilities of molecular modeling and simulation that are able to complement these bioinformatics methods, providing deeper molecular insights into the biological function of post-translational modified proteins. (C) 2017 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
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